Pattern And Incidence Of Adverse Drug Reactions Observed Due To Cardiovascular Drugs

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Prashant Ashok Pawar , Dr. Tushar Atmaram Deshmukh , Prof. Jitendra B. Naik

Abstract

Background: Cardiovascular diseases (CVD) are one of the leading causes of non-communicable disease related deaths globally. Patients with cardiovascular diseases are often prescribed multiple drugs and have higher risk for developing more adverse drug reactions. The present study aimed to monitor the incidence and pattern of adverse drug reactions (ADRs) in the cardiac care unit.
Methods: This was a prospective surveillance study that included patients of either gender who were hospitalized and prescribed at least one cardiovascular drug. The study was conducted with the permission of the Institutional Ethics Committee. Patients visiting the medicine outpatient department, cardiac clinic, medical ward, and emergency departments over a period of 24 months were recruited. ADRs were recorded on the prescribed form. A causality assessment was done using the WHO probability scale.
Results: A total of 325 patients were enrolled in the present study. Male preponderance was observed over female. Patients with age 51- 60 years experienced 83 ADRs. The most common drug class implicated in ADRs was observed due to Sacubitril/valsartan.
Conclusion: Intensive approach towards monitoring and reporting of ADRs could help healthcare professionals in minimizing preventable ADRs. There is a need for conducting such studies in more and more patients to see the pattern of ADRs in cardiac patients. More information will help in reducing the ADR occurrence and making drug use more rational and safe for patients.

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