Validated Stability Indicating FT-IR Spectroscopic Method For Simultaneous Quantitative Estimation Of Aceclofenac And Pregabalin In Combined Tablet Dosage Form

Abstract

The current study focused on FT-IR spectroscopic method development and validation for simultaneous
estimation of aceclofenac (ACF) and pregabalin (PGL) in combined tablet dosage form. Aceclofenac and
pregabalin are used in combination for the relief of pain and inflammation in rheumatoid arthritis,
osteoarthritis, and ankylosing spondylitis and adjunctive treatment of partial seizure, epilepsy,
fibromyalgia, neuropathin pain drug. Literature survey revealed that no method is reported on FTIR
method for the simultaneous estimation of the aceclofenac & pregabalin in bulk and combined
pharmaceutical dosage form. The method is validated with respect to linearity, precision, accuracy,
robustness, ruggedness and system suitability parameters as per ICH guidelines. The developed method
was applied to forced degradation studies successfully to verify the utility of the established procedure.