Simultaneous Determination Of Carbamazepine, Benzodiazepine In Perfluorodecalin By HPLC And GC-MS Techniques

Abstract

Lennox-Gastaut Syndrome (LGS) is commonly characterized by a triad of features including multiple seizure types,
intellectual disability or regression. The long-term prognosis for LGS is generally poor due to uncontrolled seizures.
During the time of such abnormal vibrations, both the seizures and the lungs suffer a lack in oxygen content to a
considerable extent. These result in prolonged vibrations and loss nervous control. As a neuro-lung protective
strategy, a novel attempt has been made to enrich both seizures and lungs with oxygen content through the
support of Perfluorodecalin (an excellent oxygen carrier) C10F18 (PFD) along with an enhancement in the
antiepileptic activity by the two chosen antiepileptic drugs (AEDs) Carbamazepine (CBZ) and Benzodiazepine (BDZ).
High Performance Liquid Chromatography (HPLC), Gas Chromatography – Mass Spectrometry (GC-MS) and Energy
dispersive X-ray Spectroscopy (EDS) studies on the emulsion produced by the sonication of both CBZ+PFD,
BDZ+PFD has been made to explore the possibility of multiple number of fluorine atoms to be physically present
though not as complete organized chemical reaction. The enrichment of oxygen content and the antiepileptic
activity is expected to be taken care by both PFD and the chosen drug respectively.