Design And Evaluation Of Trilayer Matrix Tablets Of Rosuvastatin Solid Dispersions By Geomatrix Technology

Abstract

The research work aims to enhance the aqueous solubility and sustains the drug release of BCS Class II drug
rosuvastatin. Solvent evaporation technique was used to prepare Fifteen(15) solid dispersion(SD) formulations of
rosuvastatin and evaluated for Pre formulation and Post formulation studies. In-vitro drug dissolution study
indicated a higher drug dissolution rate for SD13 of 99.74±5.39%within 60min. Eight formulations of rosuvastatin
trilayer matrix tablets(AF10-HF10) were prepared using optimized SD13 by direct compression method. These
trilayer formulations are characterize for flow properties and physic chemical parameters. The maximum drug
release was exhibited by trilayer matrix formulation (HF10) of 99.48±5.40% throughout 24hours. The optimized
formulation (HF10) had shown zero order release profile and best fitted to Higuchi and Korsmeyer-Peppa’s model.
The results demonstrated the sustainability of rosuvastatin trilayer tablets with enhanced release time and
linearity upto 24hours.