Platelet To Lymphocyte Ratio As A Predictor Of SIRS In Patients With Peptic Ulcer Perforation Underwent Surgery

Abstract

Background: The high incidence of postoperative Systemic Inflammatory Response Syndrome (SIRS) in patients with peptic ulcer perforation motivates researchers to search for inexpensive, convenient, simple, and non-invasive preoperative biomarkers that can be used to predict SIRS.
Aim: To assess the Platelet Lymphocyte Ratio (PLR) as a predictor of SIRS in patients with peptic ulcer perforation who underwent surgery at Sanglah General Hospital Denpasar.
Methods: This study used a retrospective cohort design involving 94 respondents of Peptic Ulcer Perforation patients who underwent surgery at Sanglah Hospital Denpasar from January 2016 to December 2019. The parameters in this study were age, gender, nutritional status, PLR, and occurrence of SIRS.
Results: Of all the research variables, only PLR was significant. The statistical tests obtained a p-value <0.001 and OR 37.3 (CI: 2.71-9.02). The best cut-off point is 348.5, with an AUC value of 87.5%. The OR value of 37.3 means that PLR️348.5 causes SIRS to occur 37.3 times.
Conclusion: There is a significant relationship between PLR with the incidence of SIRS, and PLR can be a predictor of SIRS incidence in PUP patients undergoing surgery