Sublingual Delivery Of Trimethyl Chitosan Chloride (Tmc) Polymeric Drops For The Quick Management Of Pain

Abstract

The goal of this study was to develop and characterize a trimethyl chitosan chloride (TMC) polymeric drops system which can deliver drug sublingually for quick management of pain. Ketorolac tromethamine (KT) is a nonsteroidal anti-inflammatory drug utilized for the management of moderate to severe pain at the opioid level. The sublingual polymeric drops were developed by utilizing TMC alongside the distinctive proportion of sweeteners and excipients. The TMC with quaternization of 37.03%, a derivative of chitosan was synthesized by two-stage reductive methylation procedure to enhance the solvency and penetrability. All the fifteen (F1-F15) formulations were characterized for taste, pH, viscosity and drug content uniformity. The optimized formulation F15 (pH=5.460.26; viscosity=23.660.57; drug content=98.78%) was chosen for further studies. The drug, polymer and excipient were checked for compatibility with FTIR, DSC, and XRD. The ex vivo permeation demonstrated that 94.70 % of drug penetrated within 30 min. The in vivo study on rat model & statistical analysis was observed for analgesic activity showing satisfactory results whereas stability study predicted slightly acceptable change in properties. From the above research examination and information investigation, it can be presumed that developed TMC polymeric drops can convey a fitting measure of medication sublingually for quick management of pain.