Wound Healing Efficacy Assessment Of Trichosanthes Dioica Fruit Extract In Anaemic Wound Model

Abstract

Wound healing, as a normal biological process in the human body, It is the process of repair that follows injury to the skin and other soft tissues. Wounds that exhibit impaired healing, including delayed acute wounds and chronic wounds, generally have failed to progress through the normal stages of healing. In the condition of iron deficiency anemia the deficiency of iron take place since Iron is a vital co-factor for proteins and enzymes involved in energy metabolism, respiration, DNA synthesis, cell cycle arrest and apoptosis. Anaemic condition in animals induced by Haloperidol drug. Methanolic extract of Tricosanthese Doica fruit treated group with showed significant increase in hydroxyproline content compared to control group (P < 0.01).Tensile strength for Group treated with methanolic extract of T. Diocia (10%)on 10th day was found to be significant (P < 0.01) than control group. The treatments with methanolic extract of T. Diocia (10%) received gel base (10%) showed complete epithilaztion process within 13 days while while it was about 22 days in control rats.