Formulation And In-Vitro Evaluation Of Self Nano Emulsifying Drug Delivery System Of Nifedipine

Abstract

The aim of the present investigation was to develop a self-nanoemulsifying drug delivery system (SNEDDS) to enhance the solubility and dissolution of poorly water-soluble nifedipine. The solubility of nifedipine in various oils was determined to identify the oil phase of SNEDDS. Various surfactants and co-surfactants were screened for their ability to emulsify the selected oil. A ternary phase diagrams were constructed to identify the efficient self-emulsifying region. The SNEDDS formulations were prepared and evaluated for various tests and final optimised formulation was chosen and characterised for FTIR, DSC, SEM and stability studies. The optimized SNEDDS formulation (F11) contained drug, sesame oil (20%), Labrasol (60) and Triton SP-135 (20%). The optimized formulation of drug-loaded SNEDDS exhibited 98.74% entrapment efficiency, 99.88% drug content and 99.86% in vitro drug release in 60 min as compared with the plain drug, which had a limited dissolution rate (31%). The degradation of nifedipine from optimized nifedipine SNEDDS formulation was significantly less when compared to the pure drug degradation. These results suggest the potential use of SNEDDS to improve dissolution and stability of poorly water-soluble nifedipine.