An Insight Into The Pharmacological Profile Of Hydroxy Cinnamic Acid, An Active Constituent Of Ferulic Acid

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Tejesvi Mishra , Chanchal Sharma , Karan Singh , Sanjeev Kumar Chauhan , K. Nagarajan , Vinay Kumar


Ferulic acid, a hydroxyl cinnamic acid derivative, belonging to the natural phenolic compound category is known for its anti-inflammatory actions. As inflammatory diseases are one of the major causes of raised chronic diseases in the human body that can be cured with the help of ferulic acid. The functional organs of the body that are more prone to pathogens due to invasive ingestions and changing lifestyles can also be treated with the help of ferulic acid. This biological native substance is active in protective measures of various acquired diseases. The anti-inflammatory effect of ferulic acid is due to the chemical structure similarity with curcumin which inhibits reactive oxygen species (ROS), inflammatory biomarkers including cytokines, inflammasomes, TNF-α, and C-reactive protein (CRP). Also, the presence of the hydroxyl cinnamic acid group within the ring helps in the suppression of free radicals during excessive free radicals’ formation. It’s anti-inflammatory and activity against oxidative stress make it a helpful and potential compound for the treatment of various neuro-inflammatory diseases such as Parkinson’s disease, Alzheimer’s disease, etc. In recent studies, it has also been found that the anti-inflammatory properties of ferulic acid can be utilized in cancer studies, immune disorders, and aging.

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