Investigation Of Anti-Ulcer Activities By Using Indomethacine Induced & Cold-Water Restraint Procedure In Experimental Rat: Meta Analysis

Abstract

Medicinal plants have long been known to be healing. Most societies have used herbs for thousands of years.  The increasing use of herbal treatments and healthcare preparations is linked to the discovery of natural items with medicinal properties. The herbal medicines of preliterate societies continue to astound us with their extensive green pharmacy. Herbal healing knowledge was passed down orally from healer to healer. Dietary and lifestyle changes can help reduce the risk of stomach ulcers. Larger than 5- millimeter cracks in stomach mucosal barrier permeate muscularis  mucosa. It is crucial to recognize that this sickness is both preventable and treated. The treatment for stomach ulcers varies depending on the etiology. The stomach membrane is easily and quickly penetrated by cold water, so this study compared mixture and omeprazole to see which had better anti-ulcer and antioxidant benefits in a rat ulcer and oxidative stress model induced by cold water immersion. Acidity of gastric juice was determined by using pH meter apparatus. Then separated and measured volume by graduated cylinder. The stomachs of the sacrificed rats were taken and immersed in 10% formalin solution and stained with hematoxylin and eosin stain for examination.