Formulation And In-Vitro Evaluation Of Candesartan Cilexetil Loaded Nanosponges For Solubility And Dissolution Enhancement

Abstract

Candesartan cilexetil (CC), a antihypertensive drug, a selective AT1 subtype angiotensine II receptor antagonist. CC is a BCS class II drug and has poor water solubility and dissolution rate, which results in a low bioavailability. In the present investigation an attempt has been made to increase the solubility of candesartan cilexetil by preparing nanosponges containing CC using ethyl cellulose and eudragit rs100 by emulsion solvent diffusion method. Nanosponges loaded with CC (CN1-CN8) were synthesized and thoroughly evaluated in terms of physicochemical attributes. Amongst all, CN3 was recognized as an optimized formulation with Particle Sizes (PS): Mean PS (756nm), Z-Average PS (1721.5nm), Poly Dispersity Index (0.844), Zeta potential (-21.1Mv), and Entrapment Efficiency (EE=85.06%).The prepared nanosponges containing CC were further characterized by FTIR, SEM image of optimized nanosponges revealed particles were spherical and spongy in nature. Saturation solubility of batches CN1-CN8 were performed and batch CN3 found to have highest solubility (10.22µg/ml). The dissolution of CN3 (78.57%) was also found to be improved as compared to pure CC (36.7%). Thus nanosponge technique may a potentially effective method for increasing solubility and dissolution rate of poorly water soluble drugs.