To Study Hematological Indices And Peripheral Smear Examination And Different Types Of Hemoglobin Variants In Microcytic Hypochromic Anemia

Abstract

To detect Hemoglobinopathies by Electrophoresis in Microcytic Hypochromic anemia in young population in the area covered by tertiary care centre at Index Medical College & Hospital. All young patients (10-30 years) who presented with pallor and were detected to have microcytic hypochromic picture on peripheral smear examination were included in the study. Microcytic hypochromic anemia is common problem in central India. The haemoglobinopathies (Structural and functional disorders of haemoglobin) are major World health problem. These are single gene, autosomal, recessive monogenic disorders that include thalassaemia and sickle cell anemia. Hemoglobinopathies  presents as microcytic hypochromic anemia. They are misdiagnosed and treated as iron deficiency anemia in hemoglobinopathies iron is not required by the body. This causes burden to the patient economically as well as on health. The excess iron which is not required by body has a toxic effect on the body.Most common cause of microcytic hypochromic anemia was iron deficiency anemia and abnormal hemoglobin disorder . Differential diagnosis based on complete hemogram and peripheral smear is possible but special tests like serum iron profile and haemoglobin electrophoresis are a must for confirmation of the diagnosis.