Synthesis And Spectroscopic Study Of Hydroxamic Acid Derivative: Cobalt (III) Sulfasalazine Hydroxamate

Abstract

Recent advances in the field of drug discovery have shed light on the capacity of hydroxamic acids to form complexes with a variety of metal ions, in particular iron, zinc, magnesium, and calcium. As a result, hydroxamic acids possess a range of distinct biological and pharmacological properties as a result of this ability (Raj et al., 2016).Strong metal ion bidentate chelators, hydroxamic acids highly chelate with Fe(III); matrix metalloproteases (MMPs), carbonic anhydrase, and tumour necrosis factor- converting enzyme (TACE), Ni(II); urease, and Cu(II) (Nef et al., 2012).Under physiological circumstances, hydroxamic acids may be quickly hydrolyzed into carboxylic acids and hydroxylamine, which is a mutagen. This property of hydroxamic acids is the primary factor that prevents these molecules from being used in therapeutic applications (Flipo et al., 2009).Recent research has demonstrated that hydroxamic acids are donors of nitric oxide,4 and that acetylated hydroxamate derivatives have the potential