Study Of Anticancer Activity Of Genistein

Abstract

Dietary polyphenols are most essential and widely studied due to their various biological activities like anti-cancerous, antibacterial, anti inflammatory, anti diabetic etc. Muramidase is a universal antimicrobial polypeptide which is found in various types of birds, mammals and insects having various pharmaceutical and pharmacological properties like anti-viral, antihistamic, anti- inflammatory, immune modulatory properties found in various types of birds, mammals and insects. It is also known that the enzyme exhibits strong anti-proliferative properties in the form of self-assembled nanostructure particles. Lysozyme has the capacity to cure various diseases by binding with various drugs and realizing them in their target site. The results of the current investigation using the skin tumour model demonstrated that a single topical administration of DMBA followed by croton oil resulted in the development of skin papillomas, which first appeared around the sixth week. By the end of the trial, the mice treated with DMBA + croton oil had a 100% tumour incidence. The total number of papillomas found in these mice was 20.These were significantly reduced in the group which received the treatment of Genistein Test Compound additionally at the dose of 50 and 100 mg/kg body weight as compared with the DMBA + croton oil group. The tumour occurrences dropped to 50% & 66% animals and the values of cumulative number of papilomas in these groups were observed 11 & 8. The average number of papillomas per mouse as well as the papillomas per papilloma-bearing mice was found to be 1.8, 1.3 and 2.7, 2.6. The average latency period was also greater with Genistein Test Compound by topical application. When the discrepancies between the experimental group 2 data were statistically examined (p < 0.05), it was discovered that they were significantly different from the control group.