To apply the method of measuring ankle-brachial blood pressure to evaluate the effectiveness and side effect of lisinopril and amlodipine combination pill.

Abstract

Aim: The aim of this study was to evaluate the antihypertensive efficacy and side effects of lisinopril and amlodipine in combination pill by method of measuring ankle-brachial blood pressure

Research objects and Methods:

40 patients with primary hypertension, mean age 69.18 ± 10.4 years. All patients had their blood pressure, pulse wave velocity (baWPV), ankle brachial index measured by pulse wave velocity VP Plus 1000 meter before receiving the treatment. All patients were then given the Lisonorm combination pill (lisinopril 10 mg and amlodipine 5 mg) for 4 weeks. After 4 weeks, the  patients was measured again with the same device (the pulse wave velocity of VP Plus 1000 meter).

Results: After 4 weeks, the values of the Right arm blood pressure decreased: 26.58 ± 9.51 mmHg/ 8.6 ± 4.47 mmHg; Left arm blood pressure decreased: 26.88 ± 11.27/13.55 ± 8.15mmHg; Right ankle blood pressure decreased: 23.75 ± 11.78/10.75 ± 6.64mmHg; Left ankle blood pressure decreased: 30.33 ± 16.64/13.6 ± 9.28mmHg; The rate of patients with the target blood pressure was 72.5% (29/40 patients). Right baPWV decreased 593.65 ± 416.59 cm/s; Left baPWV decreased 585.4 ± 447.19 cm/s.

Conclusion: The combination of lisinopril 10mg and amlodipine 5mg effectively had decreased the blood pressure in both extremities and pulse wave velocity, and had reduced vessel wall stiffness when it was measured by the pulse wave velocity VP Plus 1000 meter. The combination pill of lisinopril 10 mg and amlodipine 5 mg (Lisonorm 10/5mg) was safety and less frequent side efects than monotherapy