Isolation and identification of 1-methyl-H-Cyclopenta [b]naphthalene-4, 8-diol from the Alcoholic extract of Piper betle Linn. (Leaf stalk)

Abstract

Natural products have been a major source of drugs for centuries. The leaf stalk of Piper betle is used traditionally known to be useful for the treatment of various diseases like bad breath, boils and abscesses, conjunctivitis, constipation, headache, itches, mastitis, mastoiditis, leucorrhoea, otorrhoea, swelling of gum, rheumatism, cuts and injuries. The main objective of this work is to carry out phytochemical study of the methanol crude extract of the leaf stalk of P. betle. Phytochemical screening on this crude extract revealed the presence of phenols, alkaloids, steroids, terpenes, saponins and flavonoids. After silica gel column chromatography the crude extract led to the isolation of compounds PBT-I, (1-methyl-H-Cyclopenta [b]naphthalene-4, 8-diol). Characterization of this compound was achieved via spectroscopic methods (NMR, UV, mass spectroscopy and IR).