Quality Assesment And Designing Of Nano Topical Gels Of Psoralea Corylifolia (Bakuchi Seed), Pongamia Pinnata (Karanj Seed Oil) And Holarrhena Pubescens (Kutaja Leaves) Extract.

Abstract

Pongamia pinnata Linn and Psoralea corylifolia Linn, both from the Fabaceae family, were chosen to study their combined effects on antib acterial and anti-psoriatic activities. The goal was to create a nanogel using Psoralea Corylifolia (Bakuchi seed), Pongamia Pinnata (Karanj seed oil), and Holarrhena Pubescens (Kutaja Leaves) extracts, assess its quality and effectiveness, and formulate a topical gel for skincare. Karanja Oil is used to treat various skin conditions, while Pongamia Seed oil has insecticidal and antibacterial properties. Wrightia tinctoria (Kutaja) offers anti-psoriatic, anti-fungal, and anti-bacterial benefits, promoting collagen production to alleviate psoriasis symptoms. Bakuchi Rasayana was selected as an oral drug for the study due to its efficacy in treating skin disorders. A polyherbal nanogel was developed for transdermal drug delivery, characterized, optimized, and evaluated. Quality control tests included phytochemical analysis, physical and chemical evaluations, and antimicrobial activity testing. The nanogel showed promising results, with positive phytochemical analyses and no significant changes in the pure drug. The study suggests that the combination of Bakuchi, Kutaj, and Karanj can be effectively prepared and evaluated.