Formulation And In Vitro Evaluation Of Floating Tablets Of Itopride Hydrochloride

Abstract

Itopride Hydrochloride is a gastroprokinetic agent primarily effective in the abdomen. Due to its optimal pH ranges of 3.5-5.5, floating tablets of Itopride Hydrochloride are designed to prolong gastrointestinal residence time at specific sites, thereby enhancing plasma bioavailability. The floating tablets were formulated using the direct compression technique, incorporating hydrophilic polymers such as HPMC K4M, Carbopol 934P, and Xanthan gum to act as release-retarding agents. Effervescent agents, including sodium bicarbonate and citric acid, were used in varying ratios to optimize their impact on the drug release profile. The prepared formulations underwent a series of evaluations, including physical characterization, assay, hardness, friability, weight variation, and in vitro drug release studies. The results indicated that formulation batch F2 demonstrated an optimal drug release profile, achieving 98.20% release over 12 hours.