The Evaluation of Ethanolic Extract of Plant Piper Attenuatum for Asthma and Muscle Spasm

Abstract

The study evaluated the anti-asthmatic and muscle relaxant potential of Piper attenuatum (B.Ham.) on an animal model to justify its traditional use. Despite the introduction of synthetic drugs, none have proven full efficacy and safety. The ethanolic extract of Piper attenuatum was found to contain carbohydrates, glycosides, alkaloids, steroids, saponins, flavonoids, and proteins. It significantly inhibited histamine-induced contraction in isolated Guinea pig ileum preparation, indicating its H1 receptor antagonist property. The extract of Piper attenuatum 50, 100 & 200 mg/kg p.o. exhibited significant prolonged the latent period of convulsion followed by exposure to histamine aerosol. The maximum % protection is 88.36 of standard drug followed by 71.43, 66.96, 55.65 of P.A 50, 100, 200 mg/kg dose. Skeletal muscle relaxant activity In the case of rota rod, it was observed that the 100 mg/kg body weight showed good skeletal muscle relaxant activity when compared to control.