Formulation, stability and analytical method validation of peppermint oil solution

Abstract

Tension type headache is the most common type of headaches causing mild, moderate and intense pain in the forehead and neck. There are prescription medicines -usually nonsteroidal anti-inflammatory drugs- and herbal remedies to alleviate the pain. As peppermint (Mentha piperita L.) is one of those most used medicinal plants in the world, essential oil has also a wide range of medical applications like tension type headache. The legislation to conventional medicines applies to herbal medicinal products too, which makes registered herbal medicinal products reliable in production and quality. A CTD application dossier which contains production and quality control data in module three should be provided while registering a product in European Union. In this study a peppermint oil solution is developed and analytical method is validated to control the stability of solution indicated for tension type headaches.