Chemical Profile Of Schinus molle L. Essential Oil And Its Antihemostatic Properties

Abstract

About 17.7 million people die each year from cardiovascular disorders and the essential oils have great importance in the development of research. The aim was to evaluate the chemical composition of the essential oil from Schinus molle (EOSM) and their antihemostatic activity. EOSM was obtained from leaves by hydrodistillation and characterized by GC-FID-MS. Anticoagulant assay was performed by activated Partial Thromboplastin Time (aPTT) and Prothrombin Time (PT) assays, and the platelet aggregation assays were performed using adenosine diphosphate (ADP) and collagen as inducers. Forty-one compounds were identified mainly sesquiterpenes (88.1%) of which epi-α-cadinol (22.8%) and γ-cadinene (9.7%) are the major compounds. EOSM does not showed anticoagulant activity (40-400 mg mL-1). EOSM oil was activity against ADP inducer at 5 mg mL-1 (80%) and 40 mg mL-1 (48%), but against collagen the EOSM did was not activity. This is the first report of antiplatelet action of Schinus molle.